CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
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BRCA1/2 pathogenic variant

Gene: BRCA1/BRCA2 · Type: mutation

Indications: Breast cancer, Ovarian cancer, Prostate cancer, Pancreatic cancer

SensitivityResistanceCIViC Context

FDA Sensitivity Assertions

DrugIndicationRecommendationFDA SourceLink
OlaparibBreast cancer, Ovarian cancer, Prostate cancer, Pancreatic cancerINDICATED
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RucaparibBreast cancer, Ovarian cancer, Prostate cancer, Pancreatic cancerINDICATED
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NiraparibBreast cancer, Ovarian cancer, Prostate cancer, Pancreatic cancerINDICATED
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TalazoparibBreast cancer, Ovarian cancer, Prostate cancer, Pancreatic cancerINDICATED
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