CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Assertions

123 assertions indexed

Tier I - Level A

101 assertions
BRAFV600EPredictiveSupportsMelanomaVemurafenib,Cobimetinib
LMNA::NTRK1FusionPredictiveSupportsCancerEntrectinib
TPM3::NTRK1FusionPredictiveSupportsSolid TumorLarotrectinib
EGFRL858RPredictiveSupportsLung Non-small Cell CarcinomaGefitinib
ASPSCR1::TFE3FusionDiagnosticSupportsAlveolar Soft Part Sarcoma
v::TFE3FusionDiagnosticSupportsRenal Cell Carcinoma With MiT Translocations
v::TFEBFusionDiagnosticSupportsRenal Cell Carcinoma With MiT Translocations
YAP1::TFE3FusionDiagnosticSupportsMalignant Epithelioid Hemangioendothelioma
BRAFV600KPredictiveSupportsMelanomaVemurafenib,Cobimetinib
TCF3::PBX1FusionDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma With TCF3-PBX1
MYBRearrangementDiagnosticSupportsAngiocentric Glioma
MYBRearrangementDiagnosticSupportsDiffuse Astrocytoma, MYB- Or MYBL1-altered
MYBL1RearrangementDiagnosticSupportsDiffuse Astrocytoma, MYB- Or MYBL1-altered
YWHAEYWHAE::NUTM2DiagnosticSupportsKidney Clear Cell Sarcoma
RUNX1::RUNX1T1FusionDiagnosticSupportsAcute Myeloid Leukemia With T(8;21); (q22; Q22.1)
YAP1::vFusionDiagnosticSupportsSupratentorial Ependymoma, YAP1 Fusion–positive
BCOR::CCNB3FusionDiagnosticSupportsSarcoma With BCOR Genetic Alterations
BCOR::CCNB3FusionDiagnosticSupportsKidney Clear Cell Sarcoma
WWTR1::CAMTA1FusionDiagnosticSupportsMalignant Epithelioid Hemangioendothelioma
v::NUTM1FusionDiagnosticSupportsNUT Midline Carcinoma
SQSTM1::NTRK1FusionPredictiveSupportsSolid TumorLarotrectinib
EWSR1::CREB3L1FusionDiagnosticSupportsSclerosing Epithelioid Fibrosarcoma
FUS::CREB3L2FusionDiagnosticSupportsLow-grade Fibromyxoid Sarcoma
BRAFV600KPredictiveSupportsMelanomaTrametinib,Dabrafenib
BCR::NTRK2FusionPredictiveSupportsSolid TumorEntrectinib
MN1RearrangementDiagnosticSupportsAstroblastoma, MN1-altered
CBFA2T3::GLIS2FusionDiagnosticSupportsAcute Myeloid Leukemia With CBFA2T3::GLIS2 Fusion
MNX1::ETV6FusionDiagnosticSupportsAcute Myeloid Leukemia With MNX1::ETV6 Fusion
BCR::ABL1FusionDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma With BCR-ABL1
DEK::NUP214FusionDiagnosticSupportsAcute Myeloid Leukemia With T(6;9) (p23;q34.1)
NPM1::MLF1FusionDiagnosticSupportsAcute Myeloid Leukemia With NPM1::MLF1 Fusion
TCF3TCF3::HLFDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma With TCF3::HLF Fusion
MEF2D::vFusionDiagnosticSupportsB-lymphoblastic Leukemia With MEF2D Rearrangement
CEBPAMutationDiagnosticSupportsAcute Myeloid Leukemia With CEBPA Mutation
KAT6A::CREBBPFusionDiagnosticSupportsAML With KAT6A::CREBBP Fusion
v::NUTM1FusionDiagnosticSupportsB-lymphoblastic Leukemia With NUTM1 Rearrangement
IL3IGH::IL3DiagnosticSupportsB-lymphoblastic Leukemia/lymphoma With IGH::IL3
IGH::DUX4FusionDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma With DUX4 Rearrangements
v::IRF4FusionDiagnosticSupportsLarge B-cell Lymphoma With IRF4 Rearrangement
RBM15::MRTFAFusionDiagnosticSupportsAcute Myeloid Leukemia With T(1;22)(p13;q13)
v::JAK2FusionDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma, BCR-ABL1–like
PML::RARAFusionDiagnosticSupportsAcute Promyelocytic Leukemia With PML-RARA
FUS::ERGFusionDiagnosticSupportsAcute Myeloid Leukaemia With FUS::ERG Fusion
v::NR4A3FusionDiagnosticSupportsAcinic Cell Carcinoma
v::TFCP2FusionDiagnosticSupportsSpindle Cell Rhabdomyosarcoma
SMARCB1LOSS OF NUCLEAR PROTEIN EXPRESSIONDiagnosticSupportsCribriform Neuroepithelial Tumor
ETV6::RUNX1FusionDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma With ETV6-RUNX1
NUP98::vFusionDiagnosticSupportsAcute Myeloid Leukemia With NUP98 Rearrangement
IGH::MYCFusionDiagnosticSupportsB-lymphoblastic Leukemia With MYC Rearrangement
EPORrearrangementsDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma, BCR-ABL1–like
MECOMrearrangementDiagnosticSupportsAcute Myeloid Leukemia With MECOM Rearrangement
C19MCAlterationsDiagnosticSupportsEmbryonal Tumor With Multilayered Rosettes
KMT2A::vFusionDiagnosticSupportsAcute Myeloid Leukemia With MLL Rearrangement
COL1A1::PDGFBFusionDiagnosticSupportsDermatofibrosarcoma Protuberans
FUS::DDIT3FusionDiagnosticSupportsMyxoid Liposarcoma
ARAR-V7PredictiveSupportsProstate CancerAbiraterone,Enzalutamide
v::ZNF384FusionDiagnosticSupportsB-lymphoblastic Leukaemia/lymphoma With Other Defined Genetic Alterations
KMT2A::vFusionDiagnosticSupportsB-lymphoblastic Leukaemia/lymphoma With KMT2A Rearrangement
NPM1MUTATIONDiagnosticSupportsAcute Myeloid Leukemia With Mutated NPM1
CBFB::MYH11FusionDiagnosticSupportsAcute Myeloid Leukemia With Inv(16)(p13.1q22) Or T(16;16)(p13.1;q22)
SRF::vFusionDiagnosticSupportsMyofibroma And Myopericytoma
BCR::ABL1FusionDiagnosticSupportsChronic Myeloid Leukemia
IGH::CRLF2FusionDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma, BCR-ABL1–like
PAX3::FOXO1FusionDiagnosticSupportsAlveolar Rhabdomyosarcoma
PAX7::FOXO1FusionDiagnosticSupportsAlveolar Rhabdomyosarcoma
MYOD1L122RDiagnosticSupportsSpindle Cell Rhabdomyosarcoma
SS18::SSX1FusionDiagnosticSupportsSynovial Sarcoma
FUS::NFATC2FusionDiagnosticSupportsRound Cell Sarcoma With EWSR1-non-ETS Fusion
ERBB2AmplificationPredictiveSupportsHer2-receptor Positive Breast CancerTrastuzumab
BRAFV600EPrognosticSupportsColorectal Cancer
v::NCOA2FusionDiagnosticSupportsSpindle Cell Rhabdomyosarcoma
H3-3AG34WDiagnosticSupportsBone Giant Cell Tumor
EWSR1::PATZ1FusionDiagnosticSupportsRound Cell Sarcoma With EWSR1-non-ETS Fusion
HEY1::NCOA2FusionDiagnosticSupportsMesenchymal Chondrosarcoma
DNAJB1::PRKACAFusionDiagnosticSupportsFibrolamellar Carcinoma
v::ALKFusionPredictiveSupportsLung Non-small Cell CarcinomaCrizotinib
FLT3D835PredictiveSupportsAcute Myeloid LeukemiaGilteritinib
v::ALKFusionPredictiveSupportsLung Non-small Cell CarcinomaAlectinib
FLT3ITDPredictiveSupportsAcute Myeloid LeukemiaGilteritinib
EGFRL858RPredictiveSupportsLung Non-small Cell CarcinomaErlotinib
KANK1::NTRK2FusionPredictiveSupportsSolid TumorLarotrectinib
EML4::NTRK3FusionPredictiveSupportsSolid TumorEntrectinib
ETV6::NTRK3FusionPredictiveSupportsCongenital FibrosarcomaLarotrectinib
EML4::NTRK3FusionDiagnosticSupportsCongenital Fibrosarcoma
ETV6::NTRK3FusionDiagnosticSupportsCongenital Fibrosarcoma
EGFRL858RPredictiveSupportsLung Non-small Cell CarcinomaAfatinib
ETV6::NTRK3FusionPredictiveSupportsCongenital Mesoblastic NephromaLarotrectinib
BRAFV600EPredictiveSupportsMelanomaTrametinib,Dabrafenib
ETV6::NTRK3FusionDiagnosticSupportsCongenital Mesoblastic Nephroma
ETV6::NTRK3FusionDiagnosticSupportsBreast Secretory Carcinoma
EWSR1::WT1FusionDiagnosticSupportsDesmoplastic Small Round Cell Tumor
CIC::DUX4FusionDiagnosticSupportsCIC-rearranged Sarcoma
v::NTRK1FusionPredictiveSupportsSolid TumorLarotrectinib
BCORITDDiagnosticSupportsKidney Clear Cell Sarcoma
ZFTA::vFusionDiagnosticSupportsSupratentorial Ependymoma, ZFTA Fusion–positive
PAX5P80RDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma With PAX5 P80R
FOXR2RearrangementDiagnosticSupportsCNS Neuroblastoma With FOXR2 Activation
BCORITDDiagnosticSupportsCentral Nervous System Tumor With BCOR Internal Tandem Duplication
EWSR1::FLI1FusionDiagnosticSupportsEwing Sarcoma
EWSR1::ERGFusionDiagnosticSupportsEwing Sarcoma
LMNA::NTRK1FusionDiagnosticSupportsLipofibromatosis-like Neural Tumor

Tier II - Level C

4 assertions
FGFR1AmplificationPrognosticSupportsBreast Cancer
ETV6::NTRK3FusionPredictiveSupportsB-lymphoblastic Leukemia/lymphomaLarotrectinib
SNX2::ABL1FusionDiagnosticSupportsB-lymphoblastic Leukemia/lymphoma, BCR-ABL1–like
ACVR1G328VDiagnosticSupportsDiffuse Midline Glioma, H3 K27M-mutant

Unknown

18 assertions
LMNA::NTRK1FusionOncogenicSupportsCancer
TPR::NTRK1FusionOncogenicSupportsCancer
UFD1::NTRK2e6::e7OncogenicSupportsOsteosarcoma
RALGPS2::NTRK3e1::e4OncogenicSupportsOsteosarcoma
VHLE70K (c.208G>A)PredisposingSupportsVon Hippel-Lindau Disease
VPS18::NTRK3e4::e1OncogenicSupportsOsteosarcoma
VPS18::NTRK3e4::e18OncogenicSupportsColorectal Cancer
VHLF76del (c.227_229del)PredisposingSupportsVon Hippel-Lindau Disease
VHLQ195* (c.583C>T)PredisposingSupportsVon Hippel-Lindau Disease
VHLR167Q (c.500G>A)PredisposingSupportsVon Hippel-Lindau Disease
VHLL184P (c.551T>C)PredisposingSupportsVon Hippel-Lindau Disease
FGFR3S249COncogenicSupportsCancer
KANK1::NTRK2FusionOncogenicSupportsSolid Tumor
ETV6::NTRK3FusionOncogenicSupportsCancer
SCP2::NTRK1FusionOncogenicSupportsBreast Cancer
EML4::NTRK3FusionOncogenicSupportsSolid Tumor
QKI::NTRK2FusionOncogenicSupportsCancer
NTRK3::SCAPERFusionOncogenicSupportsPigmented Epithelioid Melanocytoma