CIViC
Compass
Tumors
Genes
Variants
Evidence
Assertions
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
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Biomarker
Germline BRCA1/2 mutation (HER2-negative breast cancer)
Gene:
BRCA1/BRCA2
· Type:
mutation
Indications: Breast cancer
Sensitivity
Resistance
CIViC Context
FDA Sensitivity Assertions
Drug
Indication
Recommendation
FDA Source
Link
Olaparib
Breast cancer
INDICATED
FDA Label
Label
Talazoparib
Breast cancer
INDICATED
FDA Label
Label