CIViC Evidence Items

15 evidence items indexed

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline

BClinical — prospective trial or retrospective cohort study

CCase study — single case report or small case series

DPreclinical — in vitro or animal model data

EInferential — computational prediction or biological rationale

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

	Predictive	Diagnostic	Prognostic	Functional	Predispos.	Oncogenic
BCR::ABL1	323	11
BRAF	186	4	26	2		1
EGFR	248		12	3		2
EML4::ALK	64
ERBB2	142		2
FLT3	55	2	21
KIT	102	3	7
KRAS	159	4	24			4
PIK3CA	156		16	4
PTEN	53	1	3	1	2	1
TP53	52		40	100	2
VHL	5	2	3		635	15

Predictive:Links a variant to treatment response or resistance

Diagnostic:Supports or refutes a specific disease diagnosis

Prognostic:Informs disease progression or clinical outcome

Functional:Characterises the biological effect of a variant

Predisposing:Germline variant associated with cancer predisposition

Oncogenic:Characterises the variant's role in oncogenesis

Level	Gene	Variant	Type	Direction	Significance	Disease	Drugs	Source
B	CTNNB1	T41A	Diagnostic	Supports	Positive	Desmoid Tumor		Lazar et al., 2008
B	CTNNB1	S45F	Diagnostic	Supports	Positive	Desmoid Tumor		Lazar et al., 2008
D	CTNNB1	Activating Mutation	Predictive	Supports	Resistance	Melanoma	Anti-CTLA-4 Monoclonal Antibody,Anti-PD-L1 Monoclonal Antibody	Spranger et al., 2015
B	CTNNB1	T41A	Diagnostic	Supports	Positive	Desmoid Tumor		Le Guellec et al., 2012
B	CTNNB1	S45F	Diagnostic	Supports	Positive	Desmoid Tumor		Le Guellec et al., 2012
B	CTNNB1	Exon 3 Mutation	Prognostic	Does Not Support	Poor Outcome	Desmoid Tumor		Mullen et al., 2013
B	CTNNB1	Exon 3 Mutation	Diagnostic	Supports	Positive	Childhood Medulloblastoma		Clifford et al., 2006
B	CTNNB1	S45F	Prognostic	Supports	Poor Outcome	Desmoid Tumor		van Broekhoven et al., 2015
B	CTNNB1	S45P	Diagnostic	Supports	Positive	Desmoid Tumor		Lazar et al., 2008
B	CTNNB1	S45F	Prognostic	Supports	Poor Outcome	Desmoid Tumor		Lazar et al., 2008
B	CTNNB1	T41A	Prognostic	Supports	Better Outcome	Desmoid Tumor		Lazar et al., 2008
B	CTNNB1	S45P	Diagnostic	Supports	Positive	Desmoid Tumor		Le Guellec et al., 2012
B	CTNNB1	Exon 3 Mutation	Diagnostic	Supports	Positive	Childhood Medulloblastoma		Fattet et al., 2009
C	CTNNB1	S45F	Predictive	Does Not Support	Sensitivity/Response	Desmoid Tumor	Meloxicam	Hamada et al., 2014
B	CTNNB1	S45P	Prognostic	Supports	Better Outcome	Desmoid Tumor		Lazar et al., 2008