CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

112 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
DKITN822KPredictiveDoes Not SupportResistanceGastrointestinal Stromal TumorPonatinibGarner et al., 2014
DKITW557_K558del AND KIT N822KPredictiveSupportsResistanceCancerRegorafenib AnhydrousGarner et al., 2014
DKITP551_E554delPMYEPredictiveDoes Not SupportSensitivity/ResponseGastrointestinal Stromal TumorImatinib,Regorafenib Anhydrous,SunitinibGarner et al., 2014
DKITK558delinsNPPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorSunitinib,Ponatinib,Imatinib,Regorafenib AnhydrousGarner et al., 2014
DKITA502_Y503dupPredictiveDoes Not SupportSensitivity/ResponseCancerPonatinib,Regorafenib Anhydrous,ImatinibGarner et al., 2014
BKITExon 11 MutationPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousBen-Ami et al., 2016
DKITN822KPredictiveDoes Not SupportSensitivity/ResponseAcute Myeloid LeukemiaSorafenib,SunitinibGozgit et al., 2011
DKITV560GPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib Anhydrous,Ponatinib,ImatinibGarner et al., 2014
DKITK642EPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorPonatinib,SunitinibGarner et al., 2014
CKITS628NPredictiveDoes Not SupportSensitivity/ResponseMelanomaImatinibVita et al., 2014
BKITEXPRESSIONPredictiveSupportsSensitivity/ResponseGlioblastomaSunitinibHutterer et al., 2014
BKITExon 11 MutationDiagnosticSupportsPositiveGastrointestinal Stromal TumorTaniguchi et al., 1999
BKITExon 11 MutationPrognosticDoes Not SupportLung CancerBoldrini et al., 2004
DKITMutationPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorImatinib,PictilisibFloris et al., 2013
CKITEXPRESSIONPredictiveSupportsSensitivity/ResponseEndometrial CancerImatinibKalender et al., 2009
CKITEXPRESSIONPredictiveSupportsSensitivity/ResponseEndometrial CancerImatinibSalvatierra et al., 2006
CKITM541LPredictiveSupportsSensitivity/ResponseChronic LeukemiaImatinibIurlo et al., 2014
CKITT417_D419delinsYPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorImatinibHeinrich et al., 2008
DKITN822HPredictiveDoes Not SupportResistanceCancerImatinibHeinrich et al., 2003
DKITN822KPredictiveDoes Not SupportSensitivity/ResponseCancerImatinibHeinrich et al., 2003
DKITD816VPredictiveSupportsResistanceCancerImatinibHeinrich et al., 2003
DKITV560GPredictiveDoes Not SupportResistanceCancerImatinibHeinrich et al., 2003
DKITK642EPredictiveDoes Not SupportResistanceCancerImatinibHeinrich et al., 2003
CKITExon 13 MutationPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorImatinibHeinrich et al., 2003
BKITExon 9 MutationPredictiveSupportsReduced SensitivityGastrointestinal Stromal TumorImatinibHeinrich et al., 2008
BKITEXPRESSIONPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorImatinibHeinrich et al., 2008
DKITW557_K558delPredictiveDoes Not SupportResistanceCancerImatinibHeinrich et al., 2003
DKITY503_F504insAYPredictiveDoes Not SupportResistanceCancerImatinibHeinrich et al., 2003
DKITD820YPredictiveSupportsSensitivity/ResponseMelanomaSunitinibAshida et al., 2009
CKITK642EPredictiveSupportsSensitivity/ResponseMucosal MelanomaImatinibLutzky et al., 2008
DKITV559DPredictiveSupportsSensitivity/ResponseCancerSunitinib,Imatinib,PD-180970,Tandutinib,DasatinibCarter et al., 2005
DKITV560_L576delPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousGarner et al., 2014
CKITK550_K558delPredictiveSupportsResistanceGastrointestinal Stromal TumorSunitinibHeinrich et al., 2008
DKITV560DPredictiveDoes Not SupportResistanceCancerSunitinibHeinrich et al., 2008
DKITW557_K558delPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib Anhydrous,SunitinibGarner et al., 2014
CKITK558_V559delPredictiveSupportsResistanceGastrointestinal Stromal TumorSunitinibHeinrich et al., 2008
DKITA502_Y503insAYPredictiveDoes Not SupportResistanceCancerSunitinibHeinrich et al., 2008
DKITP551_E554delPMYEPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorPonatinibGarner et al., 2014
CKITL576PPredictiveSupportsResistanceGastrointestinal Stromal TumorSunitinibHeinrich et al., 2008
BKITExon 9 MutationPredictiveSupportsReduced SensitivityGastrointestinal Stromal TumorRegorafenib AnhydrousGeorge et al., 2012
DKITL576PPredictiveSupportsSensitivity/ResponseCancerDasatinib,ImatinibVita et al., 2014
CKITD579delPredictiveSupportsResistanceGastrointestinal Stromal TumorSunitinibHeinrich et al., 2008
BKITWildtypePredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousBen-Ami et al., 2016
DKITV559DPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib Anhydrous,Imatinib,PonatinibGarner et al., 2014
DKITK550_W557delPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib Anhydrous,Ponatinib,Imatinib,SunitinibGarner et al., 2014
CKITD820YPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousGeorge et al., 2012
CKITN822KPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousGeorge et al., 2012
BKITExon 11 MutationPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousDemetri et al., 2013
BKITExon 9 MutationPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousDemetri et al., 2013
BKITExon 11 MutationPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib AnhydrousGeorge et al., 2012
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