CIViC Evidence Items

112 evidence items indexed

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline

BClinical — prospective trial or retrospective cohort study

CCase study — single case report or small case series

DPreclinical — in vitro or animal model data

EInferential — computational prediction or biological rationale

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

	Predictive	Diagnostic	Prognostic	Functional	Predispos.	Oncogenic
BCR::ABL1	323	11
BRAF	186	4	26	2		1
EGFR	248		12	3		2
EML4::ALK	64
ERBB2	142		2
FLT3	55	2	21
KIT	102	3	7
KRAS	159	4	24			4
PIK3CA	156		16	4
PTEN	53	1	3	1	2	1
TP53	52		40	100	2
VHL	5	2	3		635	15

Predictive:Links a variant to treatment response or resistance

Diagnostic:Supports or refutes a specific disease diagnosis

Prognostic:Informs disease progression or clinical outcome

Functional:Characterises the biological effect of a variant

Predisposing:Germline variant associated with cancer predisposition

Oncogenic:Characterises the variant's role in oncogenesis

Level	Gene	Variant	Type	Direction	Significance	Disease	Drugs	Source
D	KIT	S628N	Predictive	Supports	Sensitivity/Response	Cancer	Dasatinib,Imatinib	Vita et al., 2014
D	KIT	V560D	Predictive	Supports	Sensitivity/Response	Cancer	Imatinib Mesylate	Heinrich et al., 2008
E	KIT	M541L	Predictive	Supports	Sensitivity/Response	Colon Signet Ring Adenocarcinoma	Imatinib	Alvi et al., 2017
C	KIT	V555_V559DEL	Predictive	Supports	Resistance	Gastrointestinal Stromal Tumor	Sunitinib	Heinrich et al., 2008
C	KIT	K550_K559DEL	Predictive	Does Not Support	Resistance	Gastrointestinal Stromal Tumor	Sunitinib	Heinrich et al., 2008
D	KIT	N822K	Predictive	Supports	Sensitivity/Response	Acute Myeloid Leukemia	Ponatinib	Gozgit et al., 2011
D	KIT	A502_Y503insAY	Predictive	Supports	Sensitivity/Response	Cancer	Sunitinib	Garner et al., 2014
C	KIT	D816V	Predictive	Supports	Resistance	Cancer	Imatinib,Dasatinib	Vita et al., 2014
B	KIT	RS3733542	Predictive	Supports	Sensitivity/Response	Acute Myeloid Leukemia	Selumetinib	Jain et al., 2014
C	KIT	F506_F508DUP	Predictive	Does Not Support	Sensitivity/Response	Gastrointestinal Stromal Tumor	Imatinib	Heinrich et al., 2008
C	KIT	K484_G487DEL	Predictive	Supports	Sensitivity/Response	Gastrointestinal Stromal Tumor	Imatinib	Heinrich et al., 2008
C	KIT	K642E	Predictive	Supports	Sensitivity/Response	Melanoma	Dasatinib	Kluger et al., 2011

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