CIViC Evidence Items

194 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline

BClinical — prospective trial or retrospective cohort study

CCase study — single case report or small case series

DPreclinical — in vitro or animal model data

EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

	Predictive	Diagnostic	Prognostic	Functional	Predispos.	Oncogenic
BCR::ABL1	323	11
BRAF	186	4	26	2		1
EGFR	248		12	3		2
EML4::ALK	64
ERBB2	142		2
FLT3	55	2	21
KIT	102	3	7
KRAS	159	4	24			4
PIK3CA	156		16	4
PTEN	53	1	3	1	2	1
TP53	52		40	100	2
VHL	5	2	3		635	15

Predictive:Links a variant to treatment response or resistance

Diagnostic:Supports or refutes a specific disease diagnosis

Prognostic:Informs disease progression or clinical outcome

Functional:Characterises the biological effect of a variant

Predisposing:Germline variant associated with cancer predisposition

Oncogenic:Characterises the variant's role in oncogenesis

Level	Gene	Variant	Type	Direction	Significance	Source
D	TP53	K139E	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	P151S	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	P151H	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	P152L	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	I162F	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	Y163H	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	Y236S	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	L252F	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	E258K	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	G262D	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	G266R	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	G266E	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	A276V	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	P278S	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	L308M	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	L323P	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	Q144P	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	R158H	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	P219H	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	Y220H	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	E224K	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	Y234H	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	T230S	Functional	Does Not Support	Dominant Negative	Monti et al., 2002
D	TP53	H168Y	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	P177S	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	P177F	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	P177H	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	H179Y	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	N239S	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	S241T	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	S241F	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	C242Y	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	G244S	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	G245S	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	G245D	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	M246L	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	R273C	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	V274F	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	G279E	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	D281N	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	D281E	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	R248W	Functional	Supports	Dominant Negative	Monti et al., 2002
D	TP53	R175H	Functional	Supports	Dominant Negative	Marutani et al., 1999
D	TP53	R156H	Functional	Supports	Dominant Negative	Marutani et al., 1999
D	TP53	H178P	Functional	Supports	Dominant Negative	Marutani et al., 1999
D	TP53	H179R	Functional	Supports	Dominant Negative	Marutani et al., 1999
D	TP53	R181P	Functional	Supports	Dominant Negative	Marutani et al., 1999
D	TP53	G245S	Functional	Supports	Dominant Negative	Marutani et al., 1999
D	TP53	R249S	Functional	Supports	Dominant Negative	Marutani et al., 1999
D	TP53	E68G	Functional	Does Not Support	Dominant Negative	Marutani et al., 1999

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