CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLP138T (c.412C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLY98C (c.293A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLR69fs (c.204insG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHuang et al., 2012
CVHLSplice Region (c.340+5G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHuang et al., 2012
CVHLG144fs (c.432insG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHuang et al., 2012
CVHLQ145* (c.433C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHuang et al., 2012
CVHLExon 1 DeletionPredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHuang et al., 2012
CVHLN131K (c.393C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLC162W (c.486C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLE52K (c.154G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLE70K (c.208G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLH115Q (c.345C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLP154= (c.462A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLS65L (c.194C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLT157I (c.470C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLW88S (c.263G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLV130L (c.388G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHL*214W (c.642A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSorrell et al., 2011
CVHL*214C (c.642A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSorrell et al., 2011
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKanno et al., 1996
CVHLN78H (c.232A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKanno et al., 1996
CVHLSplice Site (c.464-1G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKanno et al., 1996
CVHLC162R (c.484T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKanno et al., 1996
CVHLSplice Site (c.464-2A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLR161G (c.481C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLC162W (c.486C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLSplice Site (c.463+2T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLSplice Site (c.464-1G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLQ132* (c.394C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLQ164* (c.490C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLQ195* (c.583C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLE70* (c.208G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLH115Y (c.343C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLC77_N78insL (c.230_231insTCT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLL178Q (c.533T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLL89P (c.266T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLP81S (c.241C>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLS80N (c.239G>A)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaGlavac et al., 1996
CVHLY98H (c.292T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLSplice Site (c.463+1G>C)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaGlavac et al., 1996
CVHLV74G (c.221T>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLN78S (c.233A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLH115R (c.344A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLV74G (c.221T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLS80N (c.239G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLS80I (c.239G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
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