CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLV84L (c.250G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLL85P (c.254T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLG93R (c.277G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLR108dup (c.322_324dup)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLL118P (c.353T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLF119L (c.357C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLD121G (c.362A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHL3'UTR alteration (c.639+10C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLE70* (c.208G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLV74G (c.221T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLS80R (c.240T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL89P (c.266T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLG93R (c.277G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLY98H (c.292T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLG114S (c.340G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLW117fs (c.349dup)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLF119L (c.357C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLD121G (c.362A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLA122I (c.364_365GC>AT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLN131K (c.393C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLQ132* (c.394C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLN150fs (c.445_458del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLI151M (c.453C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLP154L (c.461C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLSplice Site (c.464-2A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLY156C (c.467A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL158V (c.472C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLE160fs (c.479_480delAG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL163H (c.488T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL178P (c.533T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLS183* (c.548C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLQ195* (c.583C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL198Q (c.593T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLY98H (c.292T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLY112H (c.334T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLG114R (c.340G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLL118P (c.353T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLL128F (c.382C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLL129P (c.386T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLF136C (c.407T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLC162fs (c.483del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLN78I (c.233A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLN78S (c.233A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
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