CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLC162Y (c.485G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLW88FS (c.263_265delGGCinsTT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLK159fs (c.477_478insCA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLS111R (c.333C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLS65L (c.194C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLQ73FS (c.217delC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLA149fs (c.445delG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLP81S (c.241C>T) and L188V (c.562C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWeirich et al., 2002
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseJilg et al., 2012
CVHLL158fs (c.471dupT)PredisposingN/AVon Hippel-Lindau DiseaseZbar et al., 1996
CVHLV66del (c.197_220del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLF76del (c.227_229del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLV84M (c.250G>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseEisenhofer et al., 2012
CVHLI151T (c.452T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGläsker et al., 1999
CVHLE94FS (c.279delC)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseMoore et al., 2000
CVHLSplice Site (c.464-2A>G)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLG114dup (c.342dupGGT)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLSplice Site (c.341-2A>C)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaOng et al., 2007
CVHLIntronic deletion (c.341-13delCGTTTCCAACAATTTCTCGGTGT)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLSplice Site (c.464-1G>C)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLExon 3 DeletionPredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLR161= (c.481C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLE94* (c.280G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLH115R (c.344A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLI151F (c.451A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLL178R (c.533T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLP86S (c.256C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHL3'UTR alteration (c.*70C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWu et al., 2012
CVHLE70K (c.208G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseasePark et al., 2015
CVHLQ145* (c.433C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSidhu et al., 2015
CVHLN150S (c.449A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSidhu et al., 2015
CVHLV84L (c.250G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHuff et al., 2014
CVHLY98H (c.292T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLuchetti et al., 2015
CVHLSplice Site (c.464-2A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLR177ins (c.531insCTGAGAGTAAAGCCTGAA)PredisposingN/AVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLG144E (c.431G>A)PredisposingSupportsUncertain SignificanceAdrenal Gland Pheochromocytomavan der Harst et al., 1998
CVHLSplice Region (c.463+8C>T)PredisposingSupportsUncertain SignificanceAdrenal Gland Pheochromocytomavan der Harst et al., 1998
CVHLG104A (c.311G>C)PredisposingN/AVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLF91L (c.273C>G)PredisposingN/AVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLL184P (c.551T>C)DiagnosticSupportsPositiveClear Cell Renal Cell CarcinomaGallou et al., 2001
CVHLR161* (c.481C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseŞahin Atik et al., 2017
CVHLExon 3 DeletionPredisposingN/AVon Hippel-Lindau DiseaseAllasia et al., 2017
CVHLN78S (c.233A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseKobayashi et al., 2016
CVHLc.128-?_250+?PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseLee et al., 2005
CVHLY112H (c.334T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLE70K (c.208G>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseKruizinga et al., 2014
CVHLV66Gfs*89 (c.197_209del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBausch et al., 2016
CVHLF76del (c.227_229del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseBausch et al., 2016
CVHLN78S (c.233A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseBausch et al., 2016
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