CIViC Evidence Items
660 evidence items indexed
Evidence Level Distribution
CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).
AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale
Gene × Evidence Type
Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.
| Predictive | Diagnostic | Prognostic | Functional | Predispos. | Oncogenic | |
|---|---|---|---|---|---|---|
| BCR::ABL1 | 323 | 11 | ||||
| BRAF | 186 | 4 | 26 | 2 | 1 | |
| EGFR | 248 | 12 | 3 | 2 | ||
| EML4::ALK | 64 | |||||
| ERBB2 | 142 | 2 | ||||
| FLT3 | 55 | 2 | 21 | |||
| KIT | 102 | 3 | 7 | |||
| KRAS | 159 | 4 | 24 | 4 | ||
| PIK3CA | 156 | 16 | 4 | |||
| PTEN | 53 | 1 | 3 | 1 | 2 | 1 |
| TP53 | 52 | 40 | 100 | 2 | ||
| VHL | 5 | 2 | 3 | 635 | 15 |
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
| Level | Gene | Variant | Type | Direction | Significance | Disease | Drugs | Source |
|---|---|---|---|---|---|---|---|---|
| C | VHL | R79_S80del (c.236_241delGCAGTC) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | P86A (c.256C>G) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | P86S (c.256C>T) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | L89P (c.266T>C) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | D92G (c.275A>G) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | Y98H (c.292T>C) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | P138T (c.412C>A) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | R167Q (c.500G>A) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | Deletion | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | Y175* (c.525C>A) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | S65L (c.194C>T) | Predisposing | N/A | Von Hippel-Lindau Disease | Takayanagi et al., 2017 | ||
| C | VHL | S65L (c.194C>T) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Binderup et al., 2016 | |
| C | VHL | *214G (c.640T>G) | Predisposing | N/A | Von Hippel-Lindau Disease | Dannenberg et al., 2003 | ||
| C | VHL | *214C (c.641_642insC) | Predisposing | N/A | Von Hippel-Lindau Disease | Dannenberg et al., 2003 | ||
| C | VHL | S65L (c.194C>T) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Sato et al., 2013 | |
| C | VHL | L178P (c.533T>C) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | Y175* (c.525C>G) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Bausch et al., 2016 | |
| C | VHL | R167W (c.499C>T) | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | Nordstrom-O'Brien et al., 2010 | |
| C | VHL | V166F (c.496G>T) | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | Nordstrom-O'Brien et al., 2010 | |
| C | VHL | G144* (c.430G>T) | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | Nordstrom-O'Brien et al., 2010 | |
| C | VHL | F148* (c.443_455delinsA) | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | Nordstrom-O'Brien et al., 2010 | |
| C | VHL | F76del (c.227_229del) | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | Ruiz-Llorente et al., 2004 | |
| C | VHL | Null (Large deletion) | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | Erlic et al., 2010 | |
| C | VHL | Q164R (c.491A>G) | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | Chen et al., 1995 | |
| C | VHL | E55FS (c.163_164delGA) | Oncogenic | Supports | Oncogenicity | Renal Cell Carcinoma | Gallou et al., 1999 | |
| C | VHL | M54IFS (c.162_166delGGAGG) | Oncogenic | Supports | Oncogenicity | Clear Cell Renal Cell Carcinoma | Shuin et al., 1994 | |
| C | VHL | M1FS (c.1_17del17) | Oncogenic | Supports | Oncogenicity | Chromophobe Renal Cell Carcinoma | van Houwelingen et al., 2005 | |
| C | VHL | M1? (c.1-1_20del21) | Oncogenic | Supports | Oncogenicity | Clear Cell Renal Cell Carcinoma | van Houwelingen et al., 2005 | |
| C | VHL | M1? (c.3G>A) | Oncogenic | Supports | Oncogenicity | Clear Cell Renal Cell Carcinoma | Gallou et al., 2001 | |
| C | VHL | N7D (c.19A>G) | Oncogenic | Supports | Oncogenicity | Renal Cell Carcinoma | Ma et al., 2001 | |
| C | VHL | Y98FS (c.291_310del20) | Oncogenic | Supports | Oncogenicity | Clear Cell Renal Cell Carcinoma | van Houwelingen et al., 2005 | |
| C | VHL | W8* (c.24G>A) | Oncogenic | Supports | Oncogenicity | Renal Cell Carcinoma | Ma et al., 2001 | |
| C | VHL | G123fs (c.369_375delGACACAC) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Ong et al., 2007 | |
| C | VHL | L184P (c.551T>C) | Diagnostic | Supports | Positive | Renal Cell Carcinoma | Bailly et al., 1995 | |
| C | VHL | G104= (c.312C>G) | Predisposing | N/A | Von Hippel-Lindau Disease | Olschwang et al., 1998 | ||
| C | VHL | S65L (c.194C>T) | Oncogenic | Supports | Oncogenicity | Clear Cell Renal Cell Carcinoma | Gallou et al., 2001 | |
| C | VHL | F76del (c.227_229del) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | F136S (c.407T>C) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | L153P (c.458T>C) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | P154= (c.462A>C) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | V155G (c.464T>G) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | T157I (c.470C>T) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | R161G (c.481C>G) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | R161* (c.481C>T) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | C162F (c.485G>T) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | C162W (c.486C>G) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | R167L (c.500G>T) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | L169P (c.506T>C) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | V170G (c.509T>G) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 | |
| C | VHL | S183* (c.548C>A) | Predisposing | Supports | Uncertain Significance | Von Hippel-Lindau Disease | Feletti et al., 2016 |