CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHL*214L (c.641G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSorrell et al., 2011
CVHLQ164R (c.491A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSovinz et al., 2010
CVHLS80R (c.238A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLR82P (c.245G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLG104A (c.311G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLR107H (c.320G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLS111C (c.331A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLH115Q (c.345C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLV155L (c.463G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLF76del (c.227_229del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseChen et al., 2013
CVHLSplice Site (c.340+1G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLosonczy et al., 2013
CVHLR82_V84del (c.243_251del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOng et al., 2007
CVHLC77fs (c.228dup)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLL188fs (c.562delC)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOng et al., 2007
CVHLK196fs (c.584_585delAG)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOng et al., 2007
CVHLP61FS (c.182_185delCCGT)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLR161* (c.481C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNordstrom-O'Brien et al., 2010
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseZhang et al., 2015
CVHLY98FS (c.291delC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKu et al., 2013
CVHLSplice Site (c.340+1G>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseVikkath et al., 2015
CVHLV170D (c.509T>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseWittebol-Post et al., 1998
CVHLE70* (c.208G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLY156D (c.466T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLR167W (c.499C>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseNeumann et al., 2002
BVHLY98H (c.292T>C)PredisposingN/AVon Hippel-Lindau DiseaseBrauch et al., 1995
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSizdahkhani et al., 2017
CVHLY175* (c.525C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
BVHLMutationPrognosticSupportsClear Cell Renal Cell CarcinomaHakimi et al., 2013
BVHLLoss-of-functionPrognosticSupportsPoor OutcomeClear Cell Renal Cell CarcinomaSchraml et al., 2002
DVHLLossPredictiveSupportsSensitivity/ResponseRenal CarcinomaTemsirolimusThomas et al., 2006
CVHLE55RfsTer11 (c.163delG)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseZbar et al., 1996
CVHLA56FS (c.164_165insG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLExon 1 DeletionPredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNordstrom-O'Brien et al., 2010
CVHLExon 1-2 DeletionPredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNordstrom-O'Brien et al., 2010
CVHLP25L (c.74C>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLP59fs (c.173_174insC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCho et al., 2009
CVHLE55* (c.163G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLosonczy et al., 2013
CVHLY98H (c.292T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLL178P (c.533T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLN78H (c.232A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLN78S (c.233A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLS80I (c.239G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLW117C (c.351G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLL129Q (c.386insAGA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLL135* (c.404T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLN150fs (c.449del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLP154fs (c.462delA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
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