CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLE186* (c.556G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLR167fs (c.502insTTGTCCGT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLR176fs (c.526del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLS65L (c.194C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLC77fs (c.228dup)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLN78H (c.232A>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLR79P (c.236G>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLS80R (c.240T>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLL89P (c.266T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLY98H (c.292T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLG114C (c.340G>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLL118P (c.353T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLN131fs (c.390_391del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLF136S (c.407T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLL153fs (c.457delC)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLP154L (c.461C>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLL158V (c.472C>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLV170F (c.508G>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLL178P (c.533T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLI180V (c.538A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLQ195* (c.583C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLS65W (c.194C>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseMaher et al., 1996
CVHLV170D (c.509T>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseMaher et al., 1996
CVHLS65W (c.194C>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseHes et al., 2007
CVHLN78S (c.233A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseHes et al., 2007
CVHLV170D (c.509T>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseHes et al., 2007
CVHLS65* (c.194C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLE70* (c.208G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLF76S (c.227T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLR107P (c.320G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLR113* (c.337C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLL118fs (c.352_353insA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLN131T (c.392A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLT133fs (c.397del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLD143fs (c.430delG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLR161* (c.481C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLQ164* (c.490C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLY175D (c.523T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLV181fs (c.540_543del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLY185* (c.555C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLE186* (c.556G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLQ96* (c.286C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLP86R (c.257C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLG144* (c.430G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLL188P (c.563T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLS111C (c.330_331delinsTT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLG93D (c.278G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
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