CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLV170D (c.509T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseZbar et al., 1996
CVHLR64P (c.191G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLQ164* (c.490C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLQ195* (c.583C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLE189fs (c.565del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLSplice Site (c.340+1G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLG93S (c.277G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLI151T (c.452T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLL158P (c.473T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLS65L (c.194C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLS68P (c.202T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseHes et al., 2007
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLN131fs (c.390_391del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLE94* (c.280G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLP103FS (c.309_310delTG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLH115P (c.344A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLL135fs (c.404del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLR177fs (c.528del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLW88* (c.264G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLY185* (c.555C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLF76fs (c.223_224insT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCho et al., 2009
CVHLR113* (c.337C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLR120G (c.358A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLN78S (c.233A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCiotti et al., 2009
CVHLR113* (c.337C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLR161* (c.481C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLP71fs (c.211insT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLQ73* (c.217C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLQ96* (c.286C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLH191FS (c.571delC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLL118P (c.353T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLL140fs (c.417_418delTC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLK159fs (c.473dup)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLL158P (c.473T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLL188P (c.563T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLM54fs (c.161dup)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLF136S (c.407T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLP86S (c.256C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLS80R (c.238A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLS80N (c.239G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLR60FS (c.179delG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLT105P (c.313A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLW117C (c.351G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLY156D (c.466T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLY156C (c.467A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLY156* (c.468T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
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