CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLY175* (c.525C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLV166F (c.496G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLV170G (c.509T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLG114R (c.340G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCiotti et al., 2009
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseZhou et al., 2010
CVHLR177* (c.529A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseZhou et al., 2010
CVHLSplice Site (c.340+1G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseZhou et al., 2010
CVHLR113* (c.337C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLL129fs (c.384delT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLS183* (c.548C>A)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaGlavac et al., 1996
CVHLR161* (c.481C>T)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaGlavac et al., 1996
CVHLR113* (c.337C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseYoshida et al., 2000
CVHLN131S (c.392A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseYoshida et al., 2000
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseYoshida et al., 2000
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseYoshida et al., 2000
CVHLC162Y (c.485G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseYoshida et al., 2000
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseYoshida et al., 2000
CVHLR107G (c.319C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLR161P (c.482G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLQ164* (c.490C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLQ195* (c.583C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLE94* (c.280G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLG93C (c.277G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLG93S (c.277G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLG93V (c.278G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLL188V (c.562C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLL198Q (c.593T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLF119L (c.357C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLF136C (c.407T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLS65A (c.193T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLS68W (c.203C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLS80N (c.239G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLY156N (c.466T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLY156C (c.467A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLY98H (c.292T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseNeumann et al., 2002
CVHLP61fs (c.183insC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLS65* (c.194C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLE94* (c.280G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLY175* (c.525C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLV194fs (c.581_582del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLA149fs (c.449del14-nt)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLR161* (c.481C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLNull (Partial deletion of Exons 2 & 3)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLF136S (c.407T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseRocha et al., 2003
CVHLP146fs (c.437del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseRocha et al., 2003
CVHLR167W (c.499C>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseRocha et al., 2003
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseRocha et al., 2003
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