CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLExon 1 DeletionPredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseBausch et al., 2016
CVHLExon 2 DeletionPredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseBausch et al., 2016
CVHLExon 3 DeletionPredisposingN/AVon Hippel-Lindau DiseaseBausch et al., 2016
CVHLEXON 2-3 DELETIONPredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseBausch et al., 2016
CVHLExon 1-3 DeletionPredisposingN/AVon Hippel-Lindau DiseaseBausch et al., 2016
CVHLS65W (c.194C>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseBinderup et al., 2016
CVHLI151T (c.452T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseSriphrapradang et al., 2017
CVHLS65L (c.194C>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseKrzystolik et al., 2016
CVHLE70K (c.208G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLee et al., 2016
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseasePeng et al., 2017
CVHLS65L (c.194C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseasePeng et al., 2017
CVHLE70K (c.208G>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseHwang et al., 2014
CVHLF76del (c.227_229del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseHwang et al., 2014
CVHLG104V (c.311G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBahougne et al., 2018
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseIgaki et al., 2018
CVHLL188V (c.562C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLui et al., 2002
CVHLL178Q (c.533T>A)PredisposingN/AVon Hippel-Lindau DiseaseLui et al., 2002
CVHLR161Q (c.482G>A)PredisposingN/AVon Hippel-Lindau DiseaseLui et al., 2002
CVHL106insR (c.316insGCC)PredisposingN/AVon Hippel-Lindau DiseaseLui et al., 2002
CVHLN78S (c.233A>G)PredisposingN/AVon Hippel-Lindau DiseaseLui et al., 2002
CVHLC77_N78insL (c.230_231insTCT)PredisposingN/AVon Hippel-Lindau DiseaseLui et al., 2002
CVHLC162W (c.486C>G)PredisposingN/AVon Hippel-Lindau DiseaseLui et al., 2002
CVHLSplice Site (c.340+1G>A)PredisposingN/AVon Hippel-Lindau DiseaseKreusel et al., 2000
CVHLQ132P (c.395A>C)PredisposingN/AVon Hippel-Lindau DiseaseKreusel et al., 2000
CVHLR161* (c.481C>T)PredisposingN/AVon Hippel-Lindau DiseaseKreusel et al., 2000
CVHLR167W (c.499C>T)PredisposingN/AVon Hippel-Lindau DiseasePozo et al., 2005
CVHLL184P (c.551T>C)PredisposingN/AVon Hippel-Lindau DiseaseWong et al., 2008
CVHLP86S (c.256C>T)PredisposingN/AVon Hippel-Lindau DiseaseCorcos et al., 2008
CVHLR167W (c.499C>T)PredisposingN/AVon Hippel-Lindau DiseaseHuddle, 2011
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLN78S (c.233A>G)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLP81S (c.241C>T)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLP86S (c.256C>T)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLP86L (c.257C>T)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLW88S (c.263G>C)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLT157I (c.470C>T)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLC162R (c.484T>C)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLC162Y (c.485G>A)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLL178P (c.533T>C)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLNull (Large deletion)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLR120fs (c.358_359insAC)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLS80fs (c.239del)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLC77fs (c.230del)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLL118P (c.353T>C)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLQ96_P97delinsH (c.288_290del)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLG144fs (c.429_439del)PredisposingSupportsPredispositionVon Hippel-Lindau Disease1995
CVHLG114R (c.340G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLL158P (c.473T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
Page 8 of 14
PreviousNext