CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

660 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
Clear
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLN78S (c.233A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLR161* (c.481C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLR113* (c.337C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseDollfus et al., 2002
CVHLV87fs (c.255_256insC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLN150fs (c.448delA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLE55fs (c.163delG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLNull (Large deletion)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
BVHLMutationPredictiveDoes Not SupportSensitivity/ResponseRenal Cell CarcinomaPazopanibChoueiri et al., 2013
CVHLA56fs (c.164_165insA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLE55= (c.165G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLH115Q (c.345C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLF119L (c.357C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLA149T (c.445G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLN78T (c.233A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLP86A (c.256C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLW88R (c.262T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLS111N (c.332G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLC162R (c.484T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLC162F (c.485G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLC162W (c.486C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLL184P (c.551T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLE186K (c.556G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseChen et al., 1995
CVHLA56fs (c.166_167insA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCrossey et al., 1994
CVHLL101G (c.301_302delinsGG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLT105P (c.313A>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLW117C (c.351G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLC162F (c.485G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLL184P (c.551T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseStolle et al., 1998
CVHLG114C (c.340G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLI151T (c.452T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLL89P (c.266T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLP154L (c.461C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLS65L (c.194C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLW88R (c.262T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLV170G (c.509T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseOng et al., 2007
CVHLC162R (c.484T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCho et al., 2009
CVHLK196* (c.586A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCho et al., 2009
CVHLR167L (c.500G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLD126FS (c.375_376insC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLC162F (c.485G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLE160fs (c.479_480delAG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLH115Y (c.343C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLL153P (c.458T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLL169P (c.506T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLL178P (c.533T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLL184R (c.551T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLL188R (c.563T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
CVHLF136S (c.407T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseLeonardi et al., 2011
Page 9 of 14
PreviousNext