CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

4766 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
DNRG1ExpressionPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaCisplatin,Carboplatin,Gemcitabine,PaclitaxelHegde et al., 2013
DAREGExpressionPredictiveSupportsResistanceLung Non-small Cell CarcinomaCrizotinibSasaki et al., 2011
BEGFROverexpressionPrognosticSupportsPoor OutcomeHead And Neck Squamous Cell CarcinomaRubin Grandis et al., 1998
BEGFROverexpressionPredictiveDoes Not SupportSensitivity/ResponseEsophagus Squamous Cell CarcinomaNimotuzumabJia et al., 2016
BEGFROverexpressionPrognosticSupportsPoor OutcomeEsophagus Squamous Cell CarcinomaJia et al., 2016
BTGFAEXPRESSIONPrognosticSupportsPoor OutcomeHead And Neck Squamous Cell CarcinomaRubin Grandis et al., 1998
BAREGExpressionPredictiveSupportsSensitivity/ResponseColorectal CancerCetuximabPentheroudakis et al., 2013
BEREGEXPRESSIONPredictiveSupportsSensitivity/ResponseColorectal CancerCetuximabPentheroudakis et al., 2013
BMETMutationPredictiveSupportsSensitivity/ResponsePapillary Renal Cell CarcinomaForetinibChoueiri et al., 2013
CMETExon 14 Skipping MutationPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaCrizotinibPaik et al., 2015
DFGFR1ExpressionPredictiveSupportsSensitivity/ResponseHead And Neck Squamous Cell CarcinomaInfigratinibGöke et al., 2015
DFGFR3OverexpressionPredictiveSupportsSensitivity/ResponseBladder CarcinomaTyrosine Kinase Inhibitor SU5402,Dovitinib,PD173074Lamont et al., 2011
BCDKN2Ap16 ExpressionPrognosticSupportsBetter OutcomeHead And Neck Squamous Cell CarcinomaChung et al., 2014
DPTPRDMutationPredictiveSupportsSensitivity/ResponseHead And Neck CarcinomaJSI-124Peyser et al., 2015
BWEE1RS3910384PredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaPlatinum Compound,GemcitabineLiu et al., 2015
DDNMT1EXPRESSIONPredictiveSupportsSensitivity/ResponseOvarian CancerDecitabineStewart et al., 2015
DKRASMutationPredictiveSupportsSensitivity/ResponseOvarian CancerDecitabineStewart et al., 2015
BMGMTRS16906252PredictiveSupportsSensitivity/ResponseGlioblastomaTemozolomideRapkins et al., 2015
BTFF3EXPRESSIONPredictiveSupportsSensitivity/ResponseBreast CancerAminoglutethimide,TamoxifenMay et al., 2015
BDKK1NUCLEAR EXPRESSIONPredictiveSupportsResistanceColorectal CancerIrinotecan,Oxaliplatin,Levoleucovorin,FluorouracilAguilera et al., 2015
DCD44CD44s ExpressionPredictiveSupportsSensitivity/ResponseCancerRG7356Birzele et al., 2015
DEGFEXPRESSIONPredictiveSupportsResistanceHead And Neck Squamous Cell CarcinomaCetuximabAnsell et al., 2016
BMDM2EXPRESSIONPrognosticSupportsPoor OutcomeMalignant Pleural MesotheliomaWalter et al., 2015
BHMOX1EXPRESSIONPredictiveSupportsResistanceRenal Cell CarcinomaSorafenib,SunitinibZheng et al., 2015
DCASP8OverexpressionPredictiveSupportsSensitivity/ResponseEwing Sarcoma Of BoneConatumumabKang et al., 2015
BTYMSOverexpressionPredictiveSupportsResistanceLung Non-small Cell CarcinomaPemetrexedChamizo et al., 2015
DPBKOVEREXPRESSIONPredictiveSupportsResistanceLung Non-small Cell CarcinomaGefitinibLi et al., 2016
BSMARCA4UnderexpressionPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaVinorelbine,CisplatinBell et al., 2016
BSMARCA4UnderexpressionPrognosticSupportsPoor OutcomeLung Non-small Cell CarcinomaBell et al., 2016
BSETBP1Exon 4 MutationPrognosticSupportsPoor OutcomeAtypical Chronic Myeloid Leukemia, BCR-ABL1 NegativePiazza et al., 2013
DSETBP1G870SOncogenicSupportsOncogenicityChronic Myeloid LeukemiaPiazza et al., 2013
CEML4::ALKFusion AND ALK C1156YPredictiveSupportsResistanceLung Non-small Cell CarcinomaLuminespib,Ceritinib,CrizotinibShaw et al., 2016
CEML4::ALKFusion AND ALK C1156YPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaLorlatinibShaw et al., 2016
BEGFROverexpressionPredictiveDoes Not SupportSensitivity/ResponseHead And Neck Squamous Cell CarcinomaDocetaxel,CetuximabTinhofer et al., 2011
BTP53MutationPredictiveSupportsSensitivity/ResponseGastric AdenocarcinomaChemotherapyXu et al., 2014
BCDKN1AEXPRESSIONPredictiveSupportsResistanceColorectal CancerFluorouracilSim et al., 2014
BALCAMEXPRESSIONPredictiveSupportsResistanceColorectal CancerFluorouracilSim et al., 2014
BEGFRAmplificationPredictiveSupportsSensitivity/ResponseColorectal CancerPanitumumab,CetuximabShen et al., 2014
BSTMN1EXPRESSIONPredictiveSupportsResistanceEndometrial CarcinomaPaclitaxelWerner et al., 2014
BCCND1OverexpressionPredictiveSupportsResistanceEstrogen-receptor Positive Breast CancerTamoxifenStendahl et al., 2004
BCCND1AmplificationPredictiveDoes Not SupportResistanceBreast CancerTamoxifenKeilty et al., 2013
DAROVEREXPRESSIONPredictiveSupportsSensitivity/ResponseBreast CancerDactolisibWang et al., 2014
DCDKN1BCYTOPLASMIC MISLOCALIZATIONPredictiveSupportsResistanceBreast CancerLapatinibZhao et al., 2014
DNRG1ExpressionPredictiveSupportsSensitivity/ResponseCancerAnti-ErbB3 Monoclonal Antibody AV-203Meetze et al., 2015
DERBB3EXPRESSIONPredictiveDoes Not SupportSensitivity/ResponseCancerAnti-ErbB3 Monoclonal Antibody AV-203Meetze et al., 2015
BARAR-V7PredictiveSupportsResistanceProstate CancerAbiraterone,EnzalutamideAntonarakis et al., 2014
DERBB3EXPRESSIONPredictiveSupportsSensitivity/ResponsePancreatic Ductal Adenocarcinoma9F7-F11,PertuzumabThomas et al., 2014
DUGT1AEXPRESSIONPredictiveSupportsResistanceColorectal CancerGanetespibLandmann et al., 2014
DERBB4EXPRESSIONPredictiveSupportsResistanceBreast CancerLapatinibCanfield et al., 2015
BKRASRS61764370PredictiveSupportsResistanceHead And Neck Squamous Cell CarcinomaCisplatinChung et al., 2014
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