CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

4766 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
BFGFR1ExpressionPrognosticSupportsPoor OutcomeBreast CancerShi et al., 2016
CKRASA146VPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaAbemaciclibVan Allen et al., 2014
DFGFR1ExpressionPredictiveSupportsSensitivity/ResponseGastric AdenocarcinomaInfigratinibSchmidt et al., 2015
DFGFR1ExpressionPredictiveSupportsSensitivity/ResponseBladder CarcinomaPD173074,DovitinibLamont et al., 2011
DCBLCEXPRESSIONPredictiveSupportsResistanceCancerOlaparibFrankum et al., 2015
BKRASG13DPredictiveDoes Not SupportResistanceColorectal CancerCetuximabOsumi et al., 2015
BDEFA1EXPRESSIONPredictiveSupportsSensitivity/ResponseProstate CancerDocetaxelKohli et al., 2015
BERCC1ExpressionPrognosticSupportsBetter OutcomeBladder CarcinomaKlatte et al., 2015
DNOTCH1AmplificationPredictiveSupportsSensitivity/ResponseColorectal CancerNOTCH1 Antibody (PF-06293622)Arcaroli et al., 2016
BNOTCH1AmplificationPrognosticSupportsPoor OutcomeColorectal CancerArcaroli et al., 2016
BFNTBRS11623866PredictiveSupportsResistanceOvarian CancerLonafarnibBachmann et al., 2015
DPTPRTPromoter HypermethylationPredictiveSupportsSensitivity/ResponseHead And Neck Squamous Cell CarcinomaStattic,JSI-124Peyser et al., 2016
BVEGFADecreased Peri-therapeutic ExpressionPredictiveSupportsSensitivity/ResponseColorectal CancerFluorouracil,Irinotecan,Levoleucovorin,BevacizumabTsai et al., 2015
BSPHK1OVEREXPRESSIONPrognosticSupportsPoor OutcomeCervical CancerKim et al., 2015
CMETAmplificationPredictiveSupportsSensitivity/ResponseLung AdenocarcinomaCrizotinibZhang et al., 2016
CBRCA1Loss-of-functionPredictiveSupportsSensitivity/ResponseProstate CancerOlaparibMateo et al., 2015
BAREGExpressionPredictiveSupportsResistanceHead And Neck Squamous Cell CarcinomaCetuximab,DocetaxelTinhofer et al., 2011
BEGFRVIIIPredictiveSupportsResistanceHead And Neck Squamous Cell CarcinomaDocetaxel,CetuximabTinhofer et al., 2011
BRSF1AmplificationPredictiveSupportsResistanceBreast CancerTamoxifenKeilty et al., 2013
BPTENLossPredictiveSupportsResistanceGastric AdenocarcinomaTrastuzumab,LapatinibZhang et al., 2015
DERBB4NUCLEAR TRANSLOCATIONPredictiveSupportsResistanceBreast CancerTrastuzumabMohd Nafi et al., 2014
DERBB4EXPRESSIONPredictiveSupportsResistanceBreast CancerTrastuzumabMohd Nafi et al., 2014
DSLFN11EXPRESSIONPredictiveSupportsSensitivity/ResponseColorectal Cancer7-Ethyl-10-HydroxycamptothecinTian et al., 2014
DMRE11LossPredictiveSupportsSensitivity/ResponseEndometrial CancerTalazoparibKoppensteiner et al., 2014
DEGFRExon 19 DeletionPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaAfatinibBanno et al., 2015
DERBB2AmplificationPredictiveSupportsSensitivity/ResponseUterine Corpus Endometrial CarcinomaAfatinibSchwab et al., 2014
BERBB2AmplificationPredictiveSupportsSensitivity/ResponseHer2-receptor Positive Breast CancerLapatinib,Afatinib,TrastuzumabRimawi et al., 2015
BCDKN1BEXPRESSIONPredictiveSupportsSensitivity/ResponseHead And Neck Squamous Cell CarcinomaFluorouracil,CisplatinMoreno-Galindo et al., 2014
CMETAmplificationPredictiveSupportsSensitivity/ResponseLung Squamous Cell CarcinomaCrizotinibSchwab et al., 2014
BKRASMutationPredictiveDoes Not SupportSensitivity/ResponseEndometrial CancerTemsirolimus,RidaforolimusMackay et al., 2014
DFGFR1ExpressionPredictiveSupportsSensitivity/ResponseColorectal CancerInfigratinibGöke et al., 2013
BEGFRExon 18 OverexpressionPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaBevacizumab,ErlotinibBaty et al., 2013
DZEB1ExpressionPredictiveSupportsResistanceMantle Cell LymphomaGemcitabine,Doxorubicin,CytarabineSánchez-Tilló et al., 2014
DTIMP1OverexpressionPredictiveSupportsResistanceBreast CancerFulvestrantBjerre et al., 2013
DIGF1REXPRESSIONPredictiveSupportsResistanceLung Non-small Cell CarcinomaGefitinibPeled et al., 2013
BEPHB4EXPRESSIONPredictiveSupportsResistanceColorectal CancerBevacizumabGuijarro-Muñoz et al., 2013
CTYMSUnderexpressionPredictiveSupportsSensitivity/ResponseProstate CancerPemetrexedRussell et al., 2014
BTOP2AEXPRESSIONPredictiveSupportsSensitivity/ResponseBreast CancerDoxorubicinDurbecq et al., 2004
BTOP1EXPRESSIONPredictiveSupportsSensitivity/ResponseOvarian CancerTopotecan,Carboplatin,CyclophosphamideLitzow et al., 2010
EPRKAA2T172 PHOSPHORYLATIONPredictiveSupportsSensitivity/ResponseCancerACLY SiRNAMigita et al., 2013
DEIF4EBP1PHOSPHORYLATIONPredictiveSupportsSensitivity/ResponseGastric AdenocarcinomaEverolimusNishi et al., 2013
DKITMutationPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorImatinib,PictilisibFloris et al., 2013
DTUBB3EXPRESSIONPredictiveSupportsResistanceCancerPaclitaxelGanguly et al., 2011
BTUBB3EXPRESSIONPredictiveSupportsSensitivity/ResponseBreast CancerTaxane CompoundWang et al., 2013
BIGF1RNUCLEAR EXPRESSIONPredictiveSupportsSensitivity/ResponseSarcomaIGF1R Monoclonal AntibodyAsmane et al., 2012
BPROM1EXPRESSIONPredictiveSupportsResistanceHepatocellular CarcinomaSorafenibHagiwara et al., 2012
BTIMP1OverexpressionPredictiveSupportsResistanceBreast CancerPaclitaxelZhu et al., 2012
BTYMSOverexpressionPredictiveSupportsResistanceGastric AdenocarcinomaRaltitrexedShen et al., 2012
DRPS6PHOSPHORYLATIONPredictiveSupportsSensitivity/ResponseGastric AdenocarcinomaEverolimusYoon et al., 2012
DEIF4EBP1PHOSPHORYLATIONPredictiveSupportsResistanceColorectal CancerMTOR Kinase Inhibitor PP242,WYE354,DactolisibZhang et al., 2012
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