CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

4766 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
DPDGFRAD842VPredictiveSupportsResistanceCancerImatinib MesylateHeinrich et al., 2008
DPDGFRAV561DPredictiveDoes Not SupportResistanceCancerImatinib MesylateHeinrich et al., 2008
DKITV560DPredictiveSupportsSensitivity/ResponseCancerImatinib MesylateHeinrich et al., 2008
CVHLC162R (c.484T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKanno et al., 1996
BPIK3CAExon 21 Mutation AND PIK3CA Exon 10 MutationPrognosticSupportsPoor OutcomeColorectal CancerLiao et al., 2012
CVHLSplice Site (c.464-2A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLR161G (c.481C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLC162W (c.486C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLSplice Site (c.463+2T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLSplice Site (c.464-1G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLQ132* (c.394C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLQ164* (c.490C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLQ195* (c.583C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLE70* (c.208G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLH115Y (c.343C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLC77_N78insL (c.230_231insTCT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLL178Q (c.533T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLL89P (c.266T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLP81S (c.241C>T)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLS80N (c.239G>A)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaGlavac et al., 1996
CVHLY98H (c.292T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLSplice Site (c.463+1G>C)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaGlavac et al., 1996
CVHLV74G (c.221T>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLN78S (c.233A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLH115R (c.344A>G)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGlavac et al., 1996
CVHLV74G (c.221T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLS80N (c.239G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLS80I (c.239G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLV84L (c.250G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLL85P (c.254T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLG93R (c.277G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLR108dup (c.322_324dup)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLL118P (c.353T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLF119L (c.357C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLD121G (c.362A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHL3'UTR alteration (c.639+10C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseKlein et al., 2001
CVHLE70* (c.208G>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLV74G (c.221T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLF76del (c.227_229del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLS80R (c.240T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL89P (c.266T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLG93R (c.277G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLY98H (c.292T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLG114S (c.340G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLW117fs (c.349dup)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLF119L (c.357C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLD121G (c.362A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLA122I (c.364_365GC>AT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
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