CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

CIViC Evidence Items

4766 evidence items indexed

Evidence Level Distribution

CIViC evidence levels reflect study design quality, from A (strongest) to E (weakest).

AValidated — meta-analysis, systematic review, or major guideline
BClinical — prospective trial or retrospective cohort study
CCase study — single case report or small case series
DPreclinical — in vitro or animal model data
EInferential — computational prediction or biological rationale

Gene × Evidence Type

Count of CIViC evidence items per gene and evidence type category. Hover a column header for the type definition.

PredictiveDiagnosticPrognosticFunctionalPredispos.Oncogenic
BCR::ABL132311
BRAF18642621
EGFR2481232
EML4::ALK64
ERBB21422
FLT355221
KIT10237
KRAS1594244
PIK3CA156164
PTEN5313121
TP5352401002
VHL52363515
Predictive:Links a variant to treatment response or resistance
Diagnostic:Supports or refutes a specific disease diagnosis
Prognostic:Informs disease progression or clinical outcome
Functional:Characterises the biological effect of a variant
Predisposing:Germline variant associated with cancer predisposition
Oncogenic:Characterises the variant's role in oncogenesis
LevelGeneVariantTypeDirectionSignificanceDiseaseDrugsSource
CVHLN131K (c.393C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLQ132* (c.394C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLN150fs (c.445_458del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLI151M (c.453C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLP154L (c.461C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLSplice Site (c.464-2A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLY156C (c.467A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL158V (c.472C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLE160fs (c.479_480delAG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL163H (c.488T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL178P (c.533T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLS183* (c.548C>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLQ195* (c.583C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLL198Q (c.593T>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseErlic et al., 2010
CVHLY98H (c.292T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLY112H (c.334T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLG114R (c.340G>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLL118P (c.353T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLL128F (c.382C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLL129P (c.386T>C)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLF136C (c.407T>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR161Q (c.482G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLC162fs (c.483del)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR167W (c.499C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseBenhammou et al., 2010
CVHLR167Q (c.500G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLN78I (c.233A>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLN78S (c.233A>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLC162Y (c.485G>A)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLW88FS (c.263_265delGGCinsTT)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLK159fs (c.477_478insCA)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLS111R (c.333C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLS65L (c.194C>T)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLQ73FS (c.217delC)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLA149fs (c.445delG)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseCybulski et al., 2002
CVHLP81S (c.241C>T) and L188V (c.562C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseWeirich et al., 2002
CVHLS65W (c.194C>G)PredisposingSupportsPredispositionVon Hippel-Lindau DiseaseJilg et al., 2012
CVHLL158fs (c.471dupT)PredisposingN/AVon Hippel-Lindau DiseaseZbar et al., 1996
CVHLV66del (c.197_220del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLF76del (c.227_229del)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseOlschwang et al., 1998
CVHLV84M (c.250G>A)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseEisenhofer et al., 2012
CVHLI151T (c.452T>C)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseGläsker et al., 1999
CVHLE94FS (c.279delC)PredisposingSupportsUncertain SignificanceVon Hippel-Lindau DiseaseMoore et al., 2000
CVHLSplice Site (c.464-2A>G)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLG114dup (c.342dupGGT)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLSplice Site (c.341-2A>C)PredisposingSupportsUncertain SignificanceRenal Cell CarcinomaOng et al., 2007
CVHLIntronic deletion (c.341-13delCGTTTCCAACAATTTCTCGGTGT)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
CVHLSplice Site (c.464-1G>C)PredisposingN/AVon Hippel-Lindau DiseaseOng et al., 2007
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