Description
BIRC7 encodes the protein Livin which is a member of the inhibitor of apoptosis protein (IAP) family. Livin consists of a single baculoviral IAP repeat domain (BIR) and a RING domian at the C-terminus. The protein inhibits apoptosis by inhibiting proteolytic activation of capsases. Overexpression of Livin has been observed in a variety of cancers including lung, colon, and prostate compared to most normal adult tissues and has been proposed as a putative therapeutic target.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (1)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 251 | Amplification | transcript_amplification |