Description
ErbB4 (HER4) is one of the four members in the EGFR subfamily of receptor tyrosine kinases. Ligands include EGF, epiregulin, betacellulin and the neuregulins (Sundvall et. al.). Of these, NRG3 and NRG4 exclusively bind HER4 (Hynes et. al.). Mutations in ERBB4 have been identified in various cancer types including melanoma, lung adenocarcinoma and medulloblastoma. A therapeutic value of these aberrations still remains unknown (Arteaga et. al.).
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (3)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 365 | EXPRESSION | ||
| 310 | Mutation | gain_of_function_variant,transcript_variant | |
| 364 | NUCLEAR TRANSLOCATION |