Description
GATA2 is a transcription factor involved in stem cell maintenance with key roles in hematopoietic development. GATA2 mutations are associated with a variety of inherited and acquired immune disorders including myelodysplastic syndrome and acute myeloid leukemia. In addition to a role in hematopoiesis, the maintenance GATA2 expression has been implicated as a requirement in KRAS-driven non-small cell lung cancer. Preclinical models have indicated therapeutic benefit from targeting GATA2-mediated pathways in the context of KRAS-driven NSCLC.
Cyan = gene · Slate = variant · Green = drug · Click variant to filter table
Variants (1)
| CIViC ID | Name | HGVS | Type(s) |
|---|---|---|---|
| 57 | EXPRESSION |