CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/S214C

S214C

CIViC ID: 10 · Gene: ARAF

Variant Summary

Also known as
SER214CYS,RS1057519786
HGVS
NC_000023.10:g.47426121C>G,NM_001654.4:c.641C>G,NP_001645.1:p.Ser214Cys,ENST00000377045.4:c.641C>G
Variant Type(s)
missense_variant
Evidence Items
4

Evidence Level Distribution

Level C: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = ARAF and variant = S214C.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DOncogenicSupportsOncogenicityLung Cancer3
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaSorafenib3
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaTrametinib3
CPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaSorafenib2