Variant Summary
- Also known as
- GLU542LYS,RS121913273
- HGVS
- NM_006218.3:c.1624G>A,NP_006209.2:p.Glu542Lys,ENST00000263967.3:c.1624G>A,NC_000003.11:g.178936082G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 13
Evidence Level Distribution
Level A: 1Level B: 1Level C: 2Level D: 9
Evidence Items
Showing CIViC evidence rows where gene = PIK3CA and variant = E542K.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Izorlisib | 4 |
| D | Predictive | Supports | Sensitivity/Response | Thyroid Cancer | Perifosine,Temsirolimus | 3 |
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Sirolimus | 3 |
| C | Predictive | Does Not Support | Resistance | Colorectal Cancer | Cetuximab | 3 |
| A | Predictive | Supports | Sensitivity/Response | Breast Cancer | Alpelisib,Fulvestrant | 3 |
| B | Predictive | Does Not Support | Resistance | Colorectal Cancer | Regorafenib Anhydrous | 3 |
| C | Predictive | Supports | Sensitivity/Response | Head And Neck Squamous Cell Carcinoma | Apitolisib | 2 |
| D | Predictive | Supports | Sensitivity/Response | Her2-receptor Positive Breast Cancer | Pictilisib | 2 |
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | Pictilisib | 2 |
| D | Predictive | Supports | Sensitivity/Response | Her2-receptor Positive Breast Cancer | PI-103 | 1 |
| D | Predictive | Supports | Resistance | Breast Cancer | PI-103 | 1 |
| D | Predictive | Supports | Sensitivity/Response | Her2-receptor Positive Breast Cancer | PI3Ka/Di | 1 |
| D | Predictive | Supports | Sensitivity/Response | Breast Cancer | PI3Ka/Di | 1 |