Variant Summary
- Also known as
- PML-RARA
- HGVS
- —
- Variant Type(s)
- transcript_fusion
- Evidence Items
- 9
Evidence Level Distribution
Level A: 2Level B: 3Level C: 4
Evidence Items
Showing CIViC evidence rows where gene = PML::RARA and variant = Fusion.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| A | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia | 5 | |
| A | Predictive | Supports | Sensitivity/Response | Acute Promyelocytic Leukemia | Tretinoin,Arsenic Trioxide | 5 |
| B | Predictive | Supports | Sensitivity/Response | Acute Promyelocytic Leukemia | Tretinoin | 5 |
| C | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| C | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| C | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| B | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| B | Diagnostic | Supports | Positive | Acute Promyelocytic Leukemia With PML-RARA | 4 | |
| C | Predictive | Supports | Sensitivity/Response | Acute Promyelocytic Leukemia | Tretinoin | 3 |