Variant Summary
- Also known as
- RS121913377,VAL600ASP
- HGVS
- NM_004333.4:c.1799_1800delTGinsAT,NP_004324.2:p.Val600Asp,ENST00000288602.6:c.1799_1800delTGinsAT,NC_000007.13:g.140453135_140453136delinsAT
- Variant Type(s)
- missense_variant
- Evidence Items
- 5
Evidence Level Distribution
Level B: 1Level C: 2Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = BRAF and variant = V600D.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Predictive | Supports | Sensitivity/Response | Melanoma | Dabrafenib | 5 |
| D | Predictive | Supports | Sensitivity/Response | Melanoma | Vemurafenib | 4 |
| D | Predictive | Supports | Sensitivity/Response | Melanoma | Vemurafenib | 3 |
| C | Predictive | Supports | Sensitivity/Response | Melanoma | BRAF Inhibitor | 3 |
| C | Predictive | Supports | Sensitivity/Response | Melanoma | Mitogen-Activated Protein Kinase Kinase Inhibitor,BRAF Inhibitor | 3 |