CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/M918T

M918T

CIViC ID: 113 · Gene: RET

Variant Summary

Also known as
MET918THR,RS74799832
HGVS
NM_020975.4:c.2753T>C,NP_065681.1:p.Met918Thr,ENST00000355710.3:c.2753T>C,NC_000010.10:g.43617416T>C
Variant Type(s)
missense_variant
Evidence Items
9

Evidence Level Distribution

Level B: 4Level C: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = RET and variant = M918T.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DOncogenicSupportsOncogenicityCancer4
BPredictiveSupportsSensitivity/ResponseMedullary Thyroid CarcinomaCabozantinib4
DOncogenicSupportsOncogenicityCancer3
BOncogenicSupportsOncogenicityMedullary Thyroid Carcinoma3
BPredictiveSupportsSensitivity/ResponseMedullary Thyroid CarcinomaSorafenib3
DPredictiveSupportsResistanceMedullary Thyroid CarcinomaMotesanib3
DPredictiveSupportsSensitivity/ResponseMedullary Thyroid CarcinomaJAK2 Inhibitor AZD14803
CPredisposingSupportsPredispositionMedullary Thyroid Carcinoma2
BPrognosticSupportsPoor OutcomeMedullary Thyroid Carcinoma2