CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/R175H

R175H

CIViC ID: 116 · Gene: TP53

Variant Summary

Also known as
ARG175HIS,RS28934578,R43H,R136H
HGVS
NM_000546.5:c.524G>A,NP_000537.3:p.Arg175His,NC_000017.10:g.7578406C>T,ENST00000269305.4:c.524G>A
Variant Type(s)
missense_variant
Evidence Items
6

Evidence Level Distribution

Level B: 1Level C: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = TP53 and variant = R175H.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistancePharynx Squamous Cell CarcinomaMDM2 Inhibitor AMGMDS33
DFunctionalSupportsDominant Negative3
DPredictiveSupportsSensitivity/ResponseBreast CancerDoxorubicin3
BPrognosticSupportsPoor OutcomeBreast Cancer3
DPredictiveSupportsResistanceBreast AdenocarcinomaMDM2 Inhibitor AMGMDS33
CPredictiveSupportsSensitivity/ResponseStomach CarcinomaEAP Protocol0