Variant Summary
- Also known as
- ARG248TRP,RS121912651
- HGVS
- NM_000546.5:c.742C>T,NP_000537.3:p.Arg248Trp,NC_000017.10:g.7577539G>A,ENST00000269305.4:c.742C>T
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level B: 1Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = R248W.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Cancer | MDM2 Inhibitor AMGMDS3 | 4 |
| D | Functional | Supports | Dominant Negative | 3 | ||
| B | Prognostic | Supports | Poor Outcome | Breast Cancer | 3 |