Variant Summary
- Also known as
- ARG273CYS,RS121913343
- HGVS
- NM_000546.5:c.817C>T,NP_000537.3:p.Arg273Cys,NC_000017.10:g.7577121G>A,ENST00000269305.4:c.817C>T
- Variant Type(s)
- missense_variant
- Evidence Items
- 5
Evidence Level Distribution
Level B: 2Level C: 1Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = R273C.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Cancer | MDM2 Inhibitor AMGMDS3 | 4 |
| D | Functional | Supports | Dominant Negative | 3 | ||
| C | Predictive | Does Not Support | Sensitivity/Response | Stomach Carcinoma | Cisplatin,Mitomycin,Etoposide | 3 |
| B | Prognostic | Supports | Poor Outcome | Breast Cancer | 3 | |
| B | Prognostic | Supports | Poor Outcome | Breast Cancer | 3 |