Variant Summary
- Also known as
- ARG273HIS,RS28934576
- HGVS
- NM_000546.5:c.818G>A,NP_000537.3:p.Arg273His,NC_000017.10:g.7577120C>T,ENST00000269305.4:c.818G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 5
Evidence Level Distribution
Level B: 2Level D: 3
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = R273H.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Cancer | MDM2 Inhibitor AMGMDS3 | 4 |
| D | Functional | Does Not Support | Neomorphic | 4 | ||
| B | Prognostic | Supports | Poor Outcome | Breast Cancer | 3 | |
| B | Prognostic | Supports | Poor Outcome | Breast Cancer | 3 | |
| D | Predictive | Supports | Resistance | Osteosarcoma | Doxorubicin,Methotrexate | 3 |