CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/K111N

K111N

CIViC ID: 1234 · Gene: PIK3CA

Variant Summary

Also known as
LYS111ASN,RS1057519934
HGVS
NM_006218.3:c.333G>C,NP_006209.2:p.Lys111Asn,NC_000003.11:g.178916946G>C,ENST00000263967.3:c.333G>C
Variant Type(s)
missense_variant
Evidence Items
6

Evidence Level Distribution

Level D: 6

Evidence Items

Showing CIViC evidence rows where gene = PIK3CA and variant = K111N.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseHer2-receptor Positive Breast CancerPictilisib4
DPredictiveDoes Not SupportResistanceHer2-receptor Positive Breast CancerTrastuzumab Emtansine3
DPredictiveDoes Not SupportResistanceHer2-receptor Positive Breast CancerTrastuzumab,Dactolisib,Lapatinib2
DPredictiveDoes Not SupportResistanceHer2-receptor Positive Breast CancerTrastuzumab2
DPredictiveSupportsSensitivity/ResponseHer2-receptor Positive Breast CancerPI-1031
DPredictiveSupportsSensitivity/ResponseHer2-receptor Positive Breast CancerPI3Ka/Di1