CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.

I391M

CIViC ID: 1235 · Gene: PIK3CA

Variant Summary

Also known as
ILE391MET,RS2230461
HGVS
NM_006218.3:c.1173A>G,NP_006209.2:p.Ile391Met,NC_000003.11:g.178927410A>G,ENST00000263967.3:c.1173A>G
Variant Type(s)
missense_variant
Evidence Items
2

Evidence Level Distribution

Level D: 2

Evidence Items

Showing CIViC evidence rows where gene = PIK3CA and variant = I391M.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveDoes Not SupportResistanceHer2-receptor Positive Breast CancerTrastuzumab Emtansine3
DPredictiveDoes Not SupportResistanceHer2-receptor Positive Breast CancerTrastuzumab2