CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/N822K

N822K

CIViC ID: 1263 · Gene: KIT

Variant Summary

Also known as
ASN822LYS,RS121913514
HGVS
NM_000222.2:c.2466T>A,NP_000213.1:p.Asn822Lys,NC_000004.11:g.55599340T>A,ENST00000288135.5:c.2466T>A
Variant Type(s)
missense_variant
Evidence Items
7

Evidence Level Distribution

Level C: 2Level D: 5

Evidence Items

Showing CIViC evidence rows where gene = KIT and variant = N822K.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceGastrointestinal Stromal TumorSunitinib,Imatinib4
CPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib3
DPredictiveDoes Not SupportResistanceGastrointestinal Stromal TumorPonatinib3
DPredictiveDoes Not SupportSensitivity/ResponseAcute Myeloid LeukemiaSorafenib,Sunitinib3
DPredictiveDoes Not SupportSensitivity/ResponseCancerImatinib2
CPredictiveSupportsSensitivity/ResponseGastrointestinal Stromal TumorRegorafenib Anhydrous2
DPredictiveSupportsSensitivity/ResponseAcute Myeloid LeukemiaPonatinib2