CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/T670I

T670I

CIViC ID: 1267 · Gene: KIT

Variant Summary

Also known as
THR670ILE,RS121913516
HGVS
NM_000222.2:c.2009C>T,NP_000213.1:p.Thr670Ile,NC_000004.11:g.55595519C>T,ENST00000288135.5:c.2009C>T
Variant Type(s)
missense_variant
Evidence Items
4

Evidence Level Distribution

Level C: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = KIT and variant = T670I.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib5
DPredictiveDoes Not SupportResistanceGastrointestinal Stromal TumorPonatinib,Sunitinib5
DPredictiveSupportsResistanceGastrointestinal Stromal TumorRegorafenib Anhydrous4
CPredictiveSupportsResistanceGastrointestinal Stromal TumorImatinib3