CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Overexpression

Overexpression

CIViC ID: 1301 · Gene: AKT3

Variant Summary

HGVS
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Variant Type(s)
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Evidence Items
3

Evidence Level Distribution

Level D: 2Level E: 1

Evidence Items

Showing CIViC evidence rows where gene = AKT3 and variant = Overexpression.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsResistanceBreast CancerAkt Inhibitor MK22064
EPredictiveSupportsSensitivity/ResponseTriple-receptor Negative Breast CancerPan-AKT Kinase Inhibitor GSK6906934
DPredictiveSupportsResistanceMelanomaVemurafenib2