CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/G719S

G719S

CIViC ID: 134 · Gene: EGFR

Variant Summary

Also known as
GLY719SER,RS28929495
HGVS
ENST00000275493.2:c.2155G>A,NC_000007.13:g.55241707G>A,NM_005228.4:c.2155G>A,NP_005219.2:p.Gly719Ser
Variant Type(s)
missense_variant
Evidence Items
4

Evidence Level Distribution

Level B: 1Level D: 3

Evidence Items

Showing CIViC evidence rows where gene = EGFR and variant = G719S.

LevelTypeDirectionSignificanceDiseaseDrugsRating
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaGefitinib4
DPredictiveSupportsSensitivity/ResponseColorectal CancerCetuximab4
BPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaGefitinib,Erlotinib3
DPredictiveSupportsSensitivity/ResponseLung Non-small Cell CarcinomaErlotinib0