CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/G12A

G12A

CIViC ID: 148 · Gene: KRAS

Variant Summary

Also known as
GLY12ALA,RS121913529
HGVS
NM_004985.4:c.35G>C,NP_004976.2:p.Gly12Ala,NC_000012.11:g.25398284C>G,ENST00000256078.4:c.35G>C
Variant Type(s)
missense_variant
Evidence Items
9

Evidence Level Distribution

Level B: 4Level C: 1Level D: 4

Evidence Items

Showing CIViC evidence rows where gene = KRAS and variant = G12A.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPredictiveSupportsResistanceLung AdenocarcinomaGefitinib,Erlotinib3
BPredictiveSupportsResistanceColorectal CancerCetuximab3
BPredictiveSupportsResistanceLung CancerGefitinib2
BPredictiveSupportsResistanceMultiple MyelomaMelphalan2
DPredictiveSupportsResistanceMultiple MyelomaMelphalan2
DPredictiveSupportsResistanceMultiple MyelomaMelphalan2
DPredictiveSupportsResistanceMultiple MyelomaMelphalan2
DPredictiveSupportsResistanceColorectal CancerRegorafenib Anhydrous2
CPredictiveSupportsResistanceColorectal CancerPanitumumab,Cetuximab2