Variant Summary
- HGVS
- NM_005631.4:c.1234C>T,NP_005622.1:p.Leu412Phe,NC_000007.13:g.128846398C>T,ENST00000249373.3:c.1234C>T
- Variant Type(s)
- missense_variant
- Evidence Items
- 2
Evidence Level Distribution
Level C: 1Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = SMO and variant = L412F.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Basal Cell Carcinoma | Vismodegib | 0 |
| C | Predictive | Supports | Resistance | Basal Cell Carcinoma | Vismodegib | 0 |