CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/Mutation

Mutation

CIViC ID: 160 · Gene: VHL

Variant Summary

HGVS
—
Variant Type(s)
gene_variant,loss_of_function_variant
Evidence Items
5

Evidence Level Distribution

Level B: 5

Evidence Items

Showing CIViC evidence rows where gene = VHL and variant = Mutation.

LevelTypeDirectionSignificanceDiseaseDrugsRating
BPrognosticSupportsBetter OutcomeClear Cell Renal Cell Carcinoma4
BPredictiveDoes Not SupportSensitivity/ResponseRenal Cell CarcinomaAnti-VEGF Monoclonal Antibody4
BPredictiveSupportsSensitivity/ResponseRenal Cell CarcinomaEverolimus4
BPrognosticSupportsClear Cell Renal Cell Carcinoma3
BPredictiveDoes Not SupportSensitivity/ResponseRenal Cell CarcinomaPazopanib2