Variant Summary
- Also known as
- Y641,TYR646
- HGVS
- —
- Variant Type(s)
- protein_altering_variant
- Evidence Items
- 4
Evidence Level Distribution
Level B: 2Level D: 2
Evidence Items
Showing CIViC evidence rows where gene = EZH2 and variant = Y646.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| B | Diagnostic | Supports | Positive | Diffuse Large B-cell Lymphoma | 4 | |
| B | Diagnostic | Supports | Positive | Follicular Lymphoma | 4 | |
| D | Functional | Supports | Gain of Function | 3 | ||
| D | Predictive | Supports | Sensitivity/Response | Skin Melanoma | GSK126 | 2 |