Variant Summary
- Also known as
- F547 SPLICE SITE MUTATION,(C.1641+2T>G) F547 SPLICE SITE
- HGVS
- NC_000009.11:g.5070054T>G,NM_004972.3:c.1641+2T>G,NP_004963.1:p.=
- Variant Type(s)
- splice_donor_variant
- Evidence Items
- 1
Evidence Level Distribution
Level C: 1
Evidence Items
Showing CIViC evidence rows where gene = JAK2 and variant = Splice Site (c.1641+2T>G).
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predictive | Supports | Resistance | Melanoma | Pembrolizumab | 3 |