Variant Summary
- Also known as
- ARG158HIS
- HGVS
- ENST00000269305.4:c.473G>A
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level D: 3
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = R158H.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Functional | Does Not Support | Dominant Negative | 3 | ||
| D | Functional | Does Not Support | Dominant Negative | 3 | ||
| D | Predictive | Supports | Resistance | Vulva Squamous Cell Carcinoma | MDM2 Inhibitor AMGMDS3 | 3 |