Variant Summary
- HGVS
- —
- Variant Type(s)
- missense_variant
- Evidence Items
- 3
Evidence Level Distribution
Level D: 3
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = R249S.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Cancer | MDM2 Inhibitor AMGMDS3 | 4 |
| D | Functional | Supports | Dominant Negative | 3 | ||
| D | Functional | Supports | Dominant Negative | 3 |