Variant Summary
- Also known as
- R148K,R241K,ARG280LYS
- HGVS
- ENST00000269305.4:c.839G>A,NC_000017.10:g.7577099C>T,NM_000546.5:c.839G>A,NP_000537.3:p.Arg280Lys
- Variant Type(s)
- missense_variant
- Evidence Items
- 1
Evidence Level Distribution
Level D: 1
Evidence Items
Showing CIViC evidence rows where gene = TP53 and variant = R280K.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| D | Predictive | Supports | Resistance | Cancer | MDM2 Inhibitor AMGMDS3 | 4 |