CIViC Compass
Research use only — not FDA-cleared, not medical advice. Always consult FDA-approved labeling and a qualified clinician.
CIViC Variants/T157I (c.470C>T)

T157I (c.470C>T)

CIViC ID: 1745 · Gene: VHL

Variant Summary

Also known as
C.470C>T,THR157ILE,RS869025660
HGVS
NM_000551.3:c.470C>T,NP_000542.1:p.Thr157Ile,NC_000003.11:g.10191477C>T,ENST00000256474.2:c.470C>T
Variant Type(s)
missense_variant
Evidence Items
5

Evidence Level Distribution

Level C: 5

Evidence Items

Showing CIViC evidence rows where gene = VHL and variant = T157I (c.470C>T).

LevelTypeDirectionSignificanceDiseaseDrugsRating
CPredisposingSupportsPredispositionVon Hippel-Lindau Disease4
CPredisposingSupportsUncertain SignificanceVon Hippel-Lindau Disease3
CPredisposingSupportsPredispositionVon Hippel-Lindau Disease3
CPredisposingSupportsPredispositionVon Hippel-Lindau Disease2
CPredisposingSupportsUncertain SignificanceVon Hippel-Lindau Disease1