Variant Summary
- Also known as
- C.551T>C,LEU184PRO,RS1064793878
- HGVS
- NM_000551.3:c.551T>C,NP_000542.1:p.Leu184Pro,NC_000003.11:g.10191558T>C,ENST00000256474.2:c.551T>C
- Variant Type(s)
- missense_variant
- Evidence Items
- 6
Evidence Level Distribution
Level C: 6
Evidence Items
Showing CIViC evidence rows where gene = VHL and variant = L184P (c.551T>C).
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| C | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | 3 | |
| C | Predisposing | Von Hippel-Lindau Disease | 3 | |||
| C | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | 2 | |
| C | Predisposing | Supports | Predisposition | Von Hippel-Lindau Disease | 2 | |
| C | Diagnostic | Supports | Positive | Clear Cell Renal Cell Carcinoma | 2 | |
| C | Diagnostic | Supports | Positive | Renal Cell Carcinoma | 1 |