Variant Summary
- HGVS
- —
- Variant Type(s)
- transcription_variant,loss_of_function_variant
- Evidence Items
- 9
Evidence Level Distribution
Level A: 2Level B: 1Level C: 1Level D: 5
Evidence Items
Showing CIViC evidence rows where gene = ATM and variant = Mutation.
| Level | Type | Direction | Significance | Disease | Drugs | Rating |
|---|---|---|---|---|---|---|
| A | Prognostic | Supports | Poor Outcome | Chronic Lymphocytic Leukemia | 5 | |
| D | Predictive | Supports | Sensitivity/Response | Hematologic Cancer | Olaparib | 5 |
| D | Predictive | Supports | Resistance | Chronic Lymphocytic Leukemia | Doxorubicin | 4 |
| A | Predictive | Supports | Sensitivity/Response | Castration-resistant Prostate Carcinoma | Olaparib | 4 |
| D | Predictive | Supports | Sensitivity/Response | Mantle Cell Lymphoma | Olaparib | 3 |
| C | Predictive | Supports | Sensitivity/Response | Prostate Cancer | Olaparib | 3 |
| B | Prognostic | Supports | Poor Outcome | Chronic Lymphocytic Leukemia | 3 | |
| D | Predictive | Supports | Sensitivity/Response | Glioblastoma | Temozolomide | 3 |
| D | Predictive | Supports | Sensitivity/Response | Melanoma | Temozolomide | 3 |